The nasal cavity and the rhinopharynx are key sites of the initial replication of SARS-CoV-2. “We look forward to partnering and commercialising Nasitrol in the US so that healthcare professionals, caregivers for COVID patients and other individuals who are at risk can benefit.” Nasitrol mechanism of action “This rigorous, placebo-controlled study provides evidence that the simple intervention of a nasal spray with iota-carrageenan, in addition to hand hygiene, use of personal protective equipment and social distancing, could provide additional protection against transmission,” stated Dr Gustavo Mahler, Chief Executive Officer of Amcyte Pharma. The study was led by Dr Juan Figueroa of The Cesar Milstein Research Institute in Argentina and Dr Mónica Lombardo of the CEMIC University Hospital in Buenos Aires, and sponsored by the Ministry of Science, Technology and Innovation of Argentina. The incidence of COVID-19 infection was significantly lower in the Nasitrol group compared with placebo, one percent versus five percent, respectively. The primary end point was clinical COVID-19 infection, as confirmed by reverse-transcriptase-polymerase-chain-reaction (RT_PCR) testing, over 21 days. The participants were randomly assigned to receive four daily doses of Nasitrol spray or placebo for 21 days. In the new study ( NCT04590365), conducted at eight hospital ICUs in 394 clinically healthy physicians, nurses and other medical professionals who provided care to COVID-19 patients and who had not yet been vaccinated against the disease. A previous study at the US’s University of Tennessee Health Science Center found that the formulation inhibits infection by SARS-CoV-2, the virus that causes COVID-19, in vitro. Nasitrol is a patented nasal spray based on iota carrageenan, a sulfate polysaccharide synthesised by red algae, with demonstrated antiviral activity and clinical efficacy as a nasal spray in the treatment of the common cold. According to Amcyte Pharma, its Nasitrol TM nasal spray was shown to be effective in reducing COVID-19 infections among intensive care unit (ICU) staff in an independent clinical trial.
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